Prep the oven. Preheat oven to 375°F. Line a meatloaf pan with parchment paper for easy removal.
Mix the meatloaf. In a large bowl, combine meatloaf ingredients - ground beef, eggs, breadcrumbs, onion, garlic, milk, ketchup, Worcestershire sauce, parsley, paprika, Italian seasoning, salt, and pepper. Mix until everything is evenly combined.
Shape and bake. Press the mixture evenly into the prepared pan, smoothing the top. Bake the meatloaf for 40 minutes.
Make the glaze. While the meatloaf bakes, whisk together ketchup, white wine vinegar, brown sugar, garlic powder, onion powder, salt, and pepper in a small bowl.
Glaze and finish baking. Remove the meatloaf from the oven, spread the glaze evenly over the top, and return it to the oven. Bake for 10 more minutes until the internal temperature reaches 160°F.
Rest and serve. Let the meatloaf rest for 10 minutes before slicing. Spoon a little of the pan juices over each slice when serving.
Video
Notes
Use lean ground beef – About 80–90% lean works best.
Don’t overmix the meat – Mix just until combined to keep the meatloaf tender.
Check doneness – Meatloaf should reach 160°F internally.
Let it rest – Rest 10 minutes before slicing so it stays juicy.